Direct, MHC-dependent presentation of the drug sulfamethoxazole to human alphabeta T cell clones.

Direct, MHC-dependent Presentation of the Drug Sulfamethoxazole to Human ab T Cell Clones

T cells can recognize small molecular compounds like drugs. It is thought that covalent binding to MHC bound peptides is required for such a hapten stimulation. Sulfamethoxazole, like most drugs, is not chemically reactive per se, but is thought to gain the ability to covalently bind to proteins after intracellular drug metabolism. The purpose of this study was to investigate how sulfamethoxazo...

Panel of Human Proliferative T Cell Clones'

alphabeta T cell receptors as predictors of health and disease

"alphabeta T cell receptors as predictors of health and disease" (2015). The diversity of antigen receptors and the specificity it underlies are the hallmarks of the cellular arm of the adaptive immune system. T and B lymphocytes are indeed truly unique in their ability to generate receptors capable of recognizing virtually any pathogen. It has been known for several decades that T lymphocytes ...

Direct presentation regulates the magnitude of the CD8+ T cell response to cell-associated antigen through prolonged T cell proliferation.

The magnitude and complexity of Ag-specific CD8(+) T cell responses is determined by intrinsic properties of the immune system and extrinsic factors, such as vaccination. We evaluated mechanisms that regulate the CD8(+) T cell response to two distinct determinants derived from the same protein Ag, SV40 T Ag (T Ag), following immunization of C57BL/6 mice with T Ag-transformed cells. The results ...

Allele-unrestricted presentation of lidocaine by HLA-DR molecules to specific αβF T cell clones

T cells recognize peptide and non-peptide antigens. Drugs represent typical examples of nonpeptide antigens. The majority of drug-specific T cells are αβF TCR T cells and are MHC class I or II restricted. Here we show the existence of drug (lidocaine)-specific T cell clones which proliferate in the presence of antigen-presenting cells (APC) with different HLA alleles. Two clones (SFT24 and E20)...